Biosynthetic Machinery Involved in Aberrant Glycosylation: Promising Targets for Developing of Drugs Against Cancer

Cancer cells depend on altered metabolism and nutrient uptake to generate and keep the malignant phenotype. The hexosamine biosynthetic pathway is a branch of glucose metabolism that produces UDP-GlcNAc and its derivatives, UDP-GalNAc and CMP-Neu5Ac and donor substrates used in the production of gly...

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Vydáno v:Front Oncol
Hlavní autoři: Vasconcelos-dos-Santos, Andréia, Oliveira, Isadora A., Lucena, Miguel Clodomiro, Mantuano, Natalia Rodrigues, Whelan, Stephen A., Dias, Wagner Barbosa, Todeschini, Adriane Regina
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2015
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479729/
https://ncbi.nlm.nih.gov/pubmed/26161361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2015.00138
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