Hyaluronan Production Regulates Metabolic and Cancer Stem-like Properties of Breast Cancer Cells via Hexosamine Biosynthetic Pathway-coupled HIF-1 Signaling

Cancer stem cells (CSCs) represent a small subpopulation of self-renewing oncogenic cells. As in many other stem cells, metabolic reprogramming has been implicated to be a key characteristic of CSCs. However, little is known about how the metabolic features of cancer cells are controlled to orchestr...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Chanmee, Theerawut, Ontong, Pawared, Izumikawa, Tomomi, Higashide, Miho, Mochizuki, Nobutoshi, Chokchaitaweesuk, Chatchadawalai, Khansai, Manatsanan, Nakajima, Kazuki, Kakizaki, Ikuko, Kongtawelert, Prachya, Taniguchi, Naoyuki, Itano, Naoki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104936/
https://ncbi.nlm.nih.gov/pubmed/27758869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.751263
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