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Enhanced hexosamine metabolism drives metabolic and signaling networks involving hyaluronan production and O-GlcNAcylation to exacerbate breast cancer

The hexosamine biosynthetic pathway (HBP) metabolically regulates dynamic cellular events by linking nutrient availability to numerous signaling networks. Significant alterations in the HBP are often associated with cancer pathogenesis. In this study, we investigated the molecular events underlying...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Chokchaitaweesuk, Chatchadawalai, Kobayashi, Takashi, Izumikawa, Tomomi, Itano, Naoki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6811536/
https://ncbi.nlm.nih.gov/pubmed/31645543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-2034-y
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