Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland

Large-scale sequencing studies are rapidly identifying putative oncogenic mutations in human tumors. However, discrimination between passenger and driver events in tumorigenesis remains challenging and requires in vivo validation studies in reliable animal models of human cancer. In this study, we d...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Annunziato, Stefano, Kas, Sjors M., Nethe, Micha, Yücel, Hatice, Del Bravo, Jessica, Pritchard, Colin, Bin Ali, Rahmen, van Gerwen, Bas, Siteur, Bjørn, Drenth, Anne Paulien, Schut, Eva, van de Ven, Marieke, Boelens, Mirjam C., Klarenbeek, Sjoerd, Huijbers, Ivo J., van Miltenburg, Martine H., Jonkers, Jos
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Resource/Methodology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4926868/
https://ncbi.nlm.nih.gov/pubmed/27340177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.279190.116
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