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Comparative oncogenomics identifies combinations of driver genes and drug targets in BRCA1-mutated breast cancer
BRCA1-mutated breast cancer is primarily driven by DNA copy-number alterations (CNAs) containing large numbers of candidate driver genes. Validation of these candidates requires novel approaches for high-throughput in vivo perturbation of gene function. Here we develop genetically engineered mouse m...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6344487/ https://ncbi.nlm.nih.gov/pubmed/30674894 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08301-2 |
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