PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma

Invasive lobular carcinoma (ILC) is an aggressive breast cancer subtype with poor response to chemotherapy. Besides loss of E-cadherin, a hallmark of ILC, genetic inactivation of PTEN is frequently observed in patients. Through concomitant Cre-mediated inactivation of E-cadherin and PTEN in mammary...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Boelens, Mirjam C., Nethe, Micha, Klarenbeek, Sjoerd, de Ruiter, Julian R., Schut, Eva, Bonzanni, Nicola, Zeeman, Amber L., Wientjens, Ellen, van der Burg, Eline, Wessels, Lodewyk, van Amerongen, Renée, Jonkers, Jos
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4999419/
https://ncbi.nlm.nih.gov/pubmed/27524621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.07.059
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