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An in vitro method for detecting genetic toxicity based on inhibition of RNA synthesis by DNA lesions

INTRODUCTION: A wide variety of DNA lesions such as ultraviolet light-induced photoproducts and chemically induced bulky adducts and crosslinks (intrastrand and interstrand) interfere with replication and lead to mutations and cell death. In the human body, these damages may cause cancer, inborn dis...

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Bibliografski detalji
Izdano u:Genes Environ
Glavni autori: Sonohara, Yuina, Iwai, Shigenori, Kuraoka, Isao
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918014/
https://ncbi.nlm.nih.gov/pubmed/27350805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41021-015-0014-8
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