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An in vitro method for detecting genetic toxicity based on inhibition of RNA synthesis by DNA lesions

INTRODUCTION: A wide variety of DNA lesions such as ultraviolet light-induced photoproducts and chemically induced bulky adducts and crosslinks (intrastrand and interstrand) interfere with replication and lead to mutations and cell death. In the human body, these damages may cause cancer, inborn dis...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genes Environ
Prif Awduron: Sonohara, Yuina, Iwai, Shigenori, Kuraoka, Isao
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2015
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918014/
https://ncbi.nlm.nih.gov/pubmed/27350805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41021-015-0014-8
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