Acetaldehyde forms covalent GG intrastrand crosslinks in DNA

Carcinogens often generate mutable DNA lesions that contribute to cancer and aging. However, the chemical structure of tumorigenic DNA lesions formed by acetaldehyde remains unknown, although it has long been considered an environmental mutagen in alcohol, tobacco, and food. Here, we identify an ald...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Sonohara, Yuina, Yamamoto, Junpei, Tohashi, Kosuke, Takatsuka, Reine, Matsuda, Tomonari, Iwai, Shigenori, Kuraoka, Isao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345987/
https://ncbi.nlm.nih.gov/pubmed/30679737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37239-6
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