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Acetaldehyde forms covalent GG intrastrand crosslinks in DNA

Carcinogens often generate mutable DNA lesions that contribute to cancer and aging. However, the chemical structure of tumorigenic DNA lesions formed by acetaldehyde remains unknown, although it has long been considered an environmental mutagen in alcohol, tobacco, and food. Here, we identify an ald...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Sonohara, Yuina, Yamamoto, Junpei, Tohashi, Kosuke, Takatsuka, Reine, Matsuda, Tomonari, Iwai, Shigenori, Kuraoka, Isao
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345987/
https://ncbi.nlm.nih.gov/pubmed/30679737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-37239-6
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