Á lódáil...

Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3′-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease

Nucleoside/nucleotide analogs that lack the 3′-hydroxy group are widely utilized for HIV therapy. These chain-terminating nucleoside analogs (CTNAs) block DNA synthesis after their incorporation into growing DNA, leading to the antiviral effects. However, they are also considered to be DNA damaging...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Molecules
Main Authors: Yamamoto, Junpei, Takahata, Chiaki, Kuraoka, Isao, Hirota, Kouji, Iwai, Shigenori
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6273010/
https://ncbi.nlm.nih.gov/pubmed/27294910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21060766
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!