Nalaganje...
Chemical Incorporation of Chain-Terminating Nucleoside Analogs as 3′-Blocking DNA Damage and Their Removal by Human ERCC1-XPF Endonuclease
Nucleoside/nucleotide analogs that lack the 3′-hydroxy group are widely utilized for HIV therapy. These chain-terminating nucleoside analogs (CTNAs) block DNA synthesis after their incorporation into growing DNA, leading to the antiviral effects. However, they are also considered to be DNA damaging...
Shranjeno v:
| izdano v: | Molecules |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
MDPI
2016
|
| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6273010/ https://ncbi.nlm.nih.gov/pubmed/27294910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules21060766 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|