Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides

PrimPol is a DNA damage tolerance enzyme possessing both translesion synthesis (TLS) and primase activities. To uncover its potential role in TLS-mediated IgV(λ) hypermutation and define its interplay with other TLS polymerases, PrimPol(−/−) and PrimPol(−/−)/Polη(−/−)/Polζ (−/−) gene knockouts were...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Kobayashi, Kaori, Guilliam, Thomas A., Tsuda, Masataka, Yamamoto, Junpei, Bailey, Laura J., Iwai, Shigenori, Takeda, Shunichi, Doherty, Aidan J., Hirota, Kouji
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968974/
https://ncbi.nlm.nih.gov/pubmed/27230014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1191711
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados