Repriming by PrimPol is critical for DNA replication restart downstream of lesions and chain-terminating nucleosides

PrimPol is a DNA damage tolerance enzyme possessing both translesion synthesis (TLS) and primase activities. To uncover its potential role in TLS-mediated IgV(λ) hypermutation and define its interplay with other TLS polymerases, PrimPol(−/−) and PrimPol(−/−)/Polη(−/−)/Polζ (−/−) gene knockouts were...

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Publicado en:Cell Cycle
Autores principales: Kobayashi, Kaori, Guilliam, Thomas A., Tsuda, Masataka, Yamamoto, Junpei, Bailey, Laura J., Iwai, Shigenori, Takeda, Shunichi, Doherty, Aidan J., Hirota, Kouji
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2016
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Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4968974/
https://ncbi.nlm.nih.gov/pubmed/27230014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1191711
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