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PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks

DNA interstrand crosslinks (ICLs) induced by endogenous aldehydes or chemotherapeutic agents interfere with essential processes such as replication and transcription. ICL recognition and repair by the Fanconi Anemia pathway require the formation of an X‐shaped DNA structure that may arise from conve...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: González‐Acosta, Daniel, Blanco‐Romero, Elena, Ubieto‐Capella, Patricia, Mutreja, Karun, Míguez, Samuel, Llanos, Susana, García, Fernando, Muñoz, Javier, Blanco, Luis, Lopes, Massimo, Méndez, Juan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8280817/
https://ncbi.nlm.nih.gov/pubmed/34128550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106355
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