Nucleocytoplasmic transport in C9orf72-mediated ALS/FTD

A GGGGCC hexanucleotide repeat expansion in C9orf72 is the most common genetic cause of familial amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recent studies indicate that disruption of nucleocytoplasmic transport pathways play a critical role in the pathogenesis of C9orf72-...

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Bibliographic Details
Published in:Nucleus
Main Authors: Zhang, Ke, Grima, Jonathan C., Rothstein, Jeffery D., Lloyd, Thomas E.
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916865/
https://ncbi.nlm.nih.gov/pubmed/27116041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19491034.2016.1172152
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