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The C9ORF72 repeat expansion disrupts nucleocytoplasmic transport
A GGGGCC (G(4)C(2)) hexanucleotide repeat expansion (HRE) in C9ORF72 is the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Recent studies support an HRE RNA gain-of-function mechanism of neurotoxicity, and we previously identified protein interactors for...
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Publicado no: | Nature |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2015
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4800742/ https://ncbi.nlm.nih.gov/pubmed/26308891 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14973 |
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