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The expanding biology of the C9orf72 nucleotide repeat expansion in neurodegenerative disease

A nucleotide repeat expansion (NRE) within the chromosome 9 open reading frame 72 (C9orf72) gene was the first of this type of mutation to be linked to multiple neurological conditions, including amyotrophic lateral sclerosis and frontotemporal dementia. The pathogenic mechanisms through which the C...

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Detalhes bibliográficos
Publicado no:Nat Rev Neurosci
Main Authors: Haeusler, Aaron R., Donnelly, Christopher J., Rothstein, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376590/
https://ncbi.nlm.nih.gov/pubmed/27150398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrn.2016.38
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