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The expanding biology of the C9orf72 nucleotide repeat expansion in neurodegenerative disease

A nucleotide repeat expansion (NRE) within the chromosome 9 open reading frame 72 (C9orf72) gene was the first of this type of mutation to be linked to multiple neurological conditions, including amyotrophic lateral sclerosis and frontotemporal dementia. The pathogenic mechanisms through which the C...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Rev Neurosci
Prif Awduron: Haeusler, Aaron R., Donnelly, Christopher J., Rothstein, Jeffrey D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7376590/
https://ncbi.nlm.nih.gov/pubmed/27150398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrn.2016.38
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