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RNA-mediated toxicity in C9orf72 ALS and FTD
A GGGGCC hexanucleotide repeat expansion in the first intron of C9orf72 is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Compelling evidence suggests that gain of toxicity from the bidirectionally transcribed repeat expanded RNAs plays a central role in...
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| Udgivet i: | Neurobiol Dis |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7572710/ https://ncbi.nlm.nih.gov/pubmed/32829028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.105055 |
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