Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers

BACKGROUND: Loss-of-function progranulin gene (GRN) mutations have been identified as the major cause of frontotemporal lobar degeneration with transactive response (TAR) DNA-binding protein 43 (TDP-43) pathology (frontotemporal lobar degeneration [FTLD]-TDP); however, little is known about the asso...

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Vydáno v:J Psychiatry Neurosci
Hlavní autoři: Alquézar, Carolina, de la Encarnación, Ana, Moreno, Fermín, de Munain, Adolfo López, Martín-Requero, Ángeles
Médium: Artigo
Jazyk:Inglês
Vydáno: Joule Inc. 2016
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915932/
https://ncbi.nlm.nih.gov/pubmed/26624524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1503/jpn.150131
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