Progranulin Levels in Plasma and Cerebrospinal Fluid in Granulin Mutation Carriers

BACKGROUND: Pathogenic mutations in the granulin gene (GRN) are causative in 5-10% of patients with frontotemporal dementia (FTD), mostly leading to reduced progranulin protein (PGRN) levels. Upcoming therapeutic trials focus on enhancing PGRN levels. METHODS: Fluctuations in plasma PGRN (n = 41) an...

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Detalhes bibliográficos
Publicado no:Dement Geriatr Cogn Dis Extra
Main Authors: Meeter, Lieke H.H., Patzke, Holger, Loewen, Gordon, Dopper, Elise G.P., Pijnenburg, Yolande A.L., van Minkelen, Rick, van Swieten, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2016
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040889/
https://ncbi.nlm.nih.gov/pubmed/27703466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000447738
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