Progranulin Levels in Plasma and Cerebrospinal Fluid in Granulin Mutation Carriers

Background: Pathogenic mutations in the granulin gene (GRN) are causative in 5-10% of patients with frontotemporal dementia (FTD), mostly leading to reduced progranulin protein (PGRN) levels. Upcoming therapeutic trials focus on enhancing PGRN levels. Methods: Fluctuations in plasma PGRN (n = 41) an...

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Main Authors: Lieke H.H. Meeter, Holger Patzke, Gordon Loewen, Elise G.P. Dopper, Yolande A.L. Pijnenburg, Rick van Minkelen, John C. van Swieten
Formato: Artigo
Idioma:Inglês
Publicado em: Karger Publishers 2016-07-01
Colecção:Dementia and Geriatric Cognitive Disorders Extra
Assuntos:
Frontotemporal dementia
Progranulin protein
Granulin gene (GRN)
Plasma
Cerebrospinal fluid
Biomarker
Single nucleotide polymorphism
Acesso em linha:http://www.karger.com/Article/FullText/447738
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