Targeting TDP-43 phosphorylation by Casein Kinase-1δ inhibitors: a novel strategy for the treatment of frontotemporal dementia

BACKGROUND: Mutations in the progranulin gene (GRN) are the most common cause of frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). TDP-43 pathology is characterized by the hyperphosphorylation of the protein at Serine 409/410 residues. Casein kinase-1δ (CK-1δ) was reported to phos...

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Bibliographic Details
Published in:Mol Neurodegener
Main Authors: Alquezar, Carolina, Salado, Irene G., de la Encarnación, Ana, Pérez, Daniel I., Moreno, Fermín, Gil, Carmen, de Munain, Adolfo López, Martínez, Ana, Martín-Requero, Ángeles
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852436/
https://ncbi.nlm.nih.gov/pubmed/27138926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-016-0102-7
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