Inactivation of CDK/pRb Pathway Normalizes Survival Pattern of Lymphoblasts Expressing the FTLD-Progranulin Mutation c.709-1G>A

BACKGROUND: Mutations in the progranulin (PGRN) gene, leading to haploinsufficiency, cause familial frontotemporal lobar degeneration (FTLD-TDP), although the pathogenic mechanism of PGRN deficit is largely unknown. Allelic loss of PGRN was previously shown to increase the activity of cyclin-depende...

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Detalhes bibliográficos
Main Authors: Alquezar, Carolina, Esteras, Noemí, Alzualde, Ainhoa, Moreno, Fermín, Ayuso, Matilde S., López de Munain, Adolfo, Martín-Requero, Ángeles
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356399/
https://ncbi.nlm.nih.gov/pubmed/22623979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037057
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