Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents

Bacterial topoisomerase functions are required for regulation of DNA supercoiling and overcoming the DNA topological barriers that are encountered during many vital cellular processes. DNA gyrase and topoisomerase IV of the type IIA bacterial topoisomerase family are important clinical targets for a...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Sandhaus, Shayna, Annamalai, Thirunavukkarasu, Welmaker, Greg, Houghten, Richard A., Paz, Carlos, Garcia, Pamela K., Andres, Angelo, Narula, Gagandeep, Rodrigues Felix, Carolina, Geden, Sandra, Netherton, Mandy, Gupta, Rashmi, Rohde, Kyle H., Giulianotti, Marc A., Tse-Dinh, Yuk-Ching
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2016
Konular:
Experimental Therapeutics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914652/
https://ncbi.nlm.nih.gov/pubmed/27114277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00288-16
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