Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents

Bacterial topoisomerase functions are required for regulation of DNA supercoiling and overcoming the DNA topological barriers that are encountered during many vital cellular processes. DNA gyrase and topoisomerase IV of the type IIA bacterial topoisomerase family are important clinical targets for a...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Sandhaus, Shayna, Annamalai, Thirunavukkarasu, Welmaker, Greg, Houghten, Richard A., Paz, Carlos, Garcia, Pamela K., Andres, Angelo, Narula, Gagandeep, Rodrigues Felix, Carolina, Geden, Sandra, Netherton, Mandy, Gupta, Rashmi, Rohde, Kyle H., Giulianotti, Marc A., Tse-Dinh, Yuk-Ching
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914652/
https://ncbi.nlm.nih.gov/pubmed/27114277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00288-16
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