Small-Molecule Inhibitors Targeting Topoisomerase I as Novel Antituberculosis Agents

Bacterial topoisomerase functions are required for regulation of DNA supercoiling and overcoming the DNA topological barriers that are encountered during many vital cellular processes. DNA gyrase and topoisomerase IV of the type IIA bacterial topoisomerase family are important clinical targets for a...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Sandhaus, Shayna, Annamalai, Thirunavukkarasu, Welmaker, Greg, Houghten, Richard A., Paz, Carlos, Garcia, Pamela K., Andres, Angelo, Narula, Gagandeep, Rodrigues Felix, Carolina, Geden, Sandra, Netherton, Mandy, Gupta, Rashmi, Rohde, Kyle H., Giulianotti, Marc A., Tse-Dinh, Yuk-Ching
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2016
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914652/
https://ncbi.nlm.nih.gov/pubmed/27114277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00288-16
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