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The Strictly Conserved Arg-321 Residue in the Active Site of Escherichia coli Topoisomerase I Plays a Critical Role in DNA Rejoining

The strictly conserved arginine residue proximal to the active site tyrosine of type IA topoisomerases is required for the relaxation of supercoiled DNA and was hypothesized to be required for positioning of the scissile phosphate for DNA cleavage to take place. Mutants of recombinant Yersinia pesti...

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Detalhes bibliográficos
Main Authors: Narula, Gagandeep, Annamalai, Thirunavukkarasu, Aedo, Sandra, Cheng, Bokun, Sorokin, Elena, Wong, Agnes, Tse-Dinh, Yuk-Ching
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099684/
https://ncbi.nlm.nih.gov/pubmed/21478161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.229450
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