The Strictly Conserved Arg-321 Residue in the Active Site of Escherichia coli Topoisomerase I Plays a Critical Role in DNA Rejoining

The strictly conserved arginine residue proximal to the active site tyrosine of type IA topoisomerases is required for the relaxation of supercoiled DNA and was hypothesized to be required for positioning of the scissile phosphate for DNA cleavage to take place. Mutants of recombinant Yersinia pesti...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Narula, Gagandeep, Annamalai, Thirunavukkarasu, Aedo, Sandra, Cheng, Bokun, Sorokin, Elena, Wong, Agnes, Tse-Dinh, Yuk-Ching
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2011
Gaiak:
DNA and Chromosomes
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099684/
https://ncbi.nlm.nih.gov/pubmed/21478161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.229450
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