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Residues of E. coli topoisomerase I conserved for interaction with a specific cytosine base to facilitate DNA cleavage
Bacterial and archaeal topoisomerase I display selectivity for a cytosine base 4 nt upstream from the DNA cleavage site. Recently, the solved crystal structure of Escherichia coli topoisomerase I covalently linked to a single-stranded oligonucleotide revealed that R169 and R173 interact with the cyt...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3467081/ https://ncbi.nlm.nih.gov/pubmed/22833607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks688 |
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