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Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site
We have obtained new crystal structures of Mycobacterium tuberculosis topoisomerase I, including structures with ssDNA substrate bound to the active site, with and without Mg(2+) ion present. Significant enzyme conformational changes upon DNA binding place the catalytic tyrosine in a pre-transition...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6101483/ https://ncbi.nlm.nih.gov/pubmed/29905859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky492 |
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