Učitavanje...
Investigating mycobacterial topoisomerase I mechanism from the analysis of metal and DNA substrate interactions at the active site
We have obtained new crystal structures of Mycobacterium tuberculosis topoisomerase I, including structures with ssDNA substrate bound to the active site, with and without Mg(2+) ion present. Significant enzyme conformational changes upon DNA binding place the catalytic tyrosine in a pre-transition...
Spremljeno u:
| Izdano u: | Nucleic Acids Res |
|---|---|
| Glavni autori: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2018
|
| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6101483/ https://ncbi.nlm.nih.gov/pubmed/29905859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky492 |
| Oznake: |
Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!
|