Inhibition of Zn(II) Binding Type IA Topoisomerases by Organomercury Compounds and Hg(II)

Type IA topoisomerase activities are essential for resolving DNA topological barriers via an enzyme-mediated transient single strand DNA break. Accumulation of topoisomerase DNA cleavage product can lead to cell death or genomic rearrangement. Many antibacterial and anticancer drugs act as topoisome...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Cheng, Bokun, Annamalai, Thirunavukkarasu, Sandhaus, Shayna, Bansod, Priyanka, Tse-Dinh, Yuk-Ching
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2015
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4370478/
https://ncbi.nlm.nih.gov/pubmed/25798600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120022
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