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Synthesis and antibacterial evaluation of anziaic acid and analogues as topoisomerase I inhibitors
Naturally occurring anziaic acid was very recently reported as a topoisomerase I inhibitor with antibacterial activity. Herein total synthesis of anziaic acid and structural analogues is described and the preliminary structure-activity relationship (SAR) has been developed based on topoisomerase inh...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3867937/ https://ncbi.nlm.nih.gov/pubmed/24363888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C3MD00238A |
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