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Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor

Topoisomerase inhibitors are effective for antibacterial and anticancer therapy because they can lead to the accumulation of the intermediate DNA cleavage complex formed by the topoisomerase enzymes, which trigger cell death. Here we report the application of a novel enzyme-based high-throughput scr...

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Autori principali: Cheng, Bokun, Cao, Shugeng, Vasquez, Victor, Annamalai, Thirunavukkarasu, Tamayo-Castillo, Giselle, Clardy, Jon, Tse-Dinh, Yuk-Ching
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620467/
https://ncbi.nlm.nih.gov/pubmed/23593306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060770
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