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Identification of Anziaic Acid, a Lichen Depside from Hypotrachyna sp., as a New Topoisomerase Poison Inhibitor

Topoisomerase inhibitors are effective for antibacterial and anticancer therapy because they can lead to the accumulation of the intermediate DNA cleavage complex formed by the topoisomerase enzymes, which trigger cell death. Here we report the application of a novel enzyme-based high-throughput scr...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Cheng, Bokun, Cao, Shugeng, Vasquez, Victor, Annamalai, Thirunavukkarasu, Tamayo-Castillo, Giselle, Clardy, Jon, Tse-Dinh, Yuk-Ching
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Public Library of Science 2013
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3620467/
https://ncbi.nlm.nih.gov/pubmed/23593306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060770
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