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Inhibition of Zn(II) Binding Type IA Topoisomerases by Organomercury Compounds and Hg(II)
Type IA topoisomerase activities are essential for resolving DNA topological barriers via an enzyme-mediated transient single strand DNA break. Accumulation of topoisomerase DNA cleavage product can lead to cell death or genomic rearrangement. Many antibacterial and anticancer drugs act as topoisome...
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| Pubblicato in: | PLoS One |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4370478/ https://ncbi.nlm.nih.gov/pubmed/25798600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120022 |
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