Inhibition of Rb phosphorylation leads to mTORC2-mediated activation of Akt

The retinoblastoma (Rb) protein exerts its tumor suppressor function primarily by inhibiting the E2F family of transcription factors that govern cell cycle progression. However, it remains largely elusive whether hyper-phosphorylated, non-E2F1-interacting form, of Rb has any physiological role. Here...

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Publicat a:Mol Cell
Autors principals: Zhang, Jinfang, Xu, Kai, Liu, Pengda, Geng, Yan, Wang, Bin, Gan, Wenjian, Guo, Jianping, Wu, Fei, Chin, Y. Rebecca, Berrios, Christian, Lien, Evan C., Toker, Alex, DeCaprio, James A., Sicinski, Piotr, Wei, Wenyi
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912424/
https://ncbi.nlm.nih.gov/pubmed/27237051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.023
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