Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis

The mechanistic target of rapamycin (mTOR) functions as a critical regulator of cellular growth and metabolism by forming multi-component, yet functionally distinct complexes mTORC1 and mTORC2. Although mTORC2 has been implicated in mTORC1 activation, little is known about how mTORC2 is regulated. H...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Liu, Pengda, Gan, Wenjian, Inuzuka, Hiroyuki, Lazorchak, Adam S, Gao, Daming, Arojo, Omotooke, Liu, Dou, Wan, Lixin, Zhai, Bo, Yu, Yonghao, Yuan, Min, Kim, Byeong Mo, Shaik, Shavali, Menon, Suchithra, Gygi, Steven P., Lee, Tae Ho, Asara, John M, Manning, Brendan D., Blenis, John, Su, Bing, Wei, Wenyi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827117/
https://ncbi.nlm.nih.gov/pubmed/24161930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2860
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky