Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis

The mechanistic target of rapamycin (mTOR) functions as a critical regulator of cellular growth and metabolism by forming multi-component, yet functionally distinct complexes mTORC1 and mTORC2. Although mTORC2 has been implicated in mTORC1 activation, little is known about how mTORC2 is regulated. H...

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Detalhes bibliográficos
Main Authors: Liu, Pengda, Gan, Wenjian, Inuzuka, Hiroyuki, Lazorchak, Adam S, Gao, Daming, Arojo, Omotooke, Liu, Dou, Wan, Lixin, Zhai, Bo, Yu, Yonghao, Yuan, Min, Kim, Byeong Mo, Shaik, Shavali, Menon, Suchithra, Gygi, Steven P., Lee, Tae Ho, Asara, John M, Manning, Brendan D., Blenis, John, Su, Bing, Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827117/
https://ncbi.nlm.nih.gov/pubmed/24161930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2860
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