Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis

The mechanistic target of rapamycin (mTOR) functions as a critical regulator of cellular growth and metabolism by forming multi-component, yet functionally distinct complexes mTORC1 and mTORC2. Although mTORC2 has been implicated in mTORC1 activation, little is known about how mTORC2 is regulated. H...

Full description

Saved in:
Bibliographic Details
Main Authors: Liu, Pengda, Gan, Wenjian, Inuzuka, Hiroyuki, Lazorchak, Adam S, Gao, Daming, Arojo, Omotooke, Liu, Dou, Wan, Lixin, Zhai, Bo, Yu, Yonghao, Yuan, Min, Kim, Byeong Mo, Shaik, Shavali, Menon, Suchithra, Gygi, Steven P., Lee, Tae Ho, Asara, John M, Manning, Brendan D., Blenis, John, Su, Bing, Wei, Wenyi
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827117/
https://ncbi.nlm.nih.gov/pubmed/24161930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2860
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items