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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals
The mechanistic target of rapamycin complex 1 (mTORC1) stimulates a coordinated anabolic program in response to growth-promoting signals. Paradoxically, recent studies indicate that mTORC1 can activate the transcription factor ATF4 through mechanisms distinct from its canonical induction by the inte...
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| Veröffentlicht in: | eLife |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
eLife Sciences Publications, Ltd
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7997658/ https://ncbi.nlm.nih.gov/pubmed/33646118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.63326 |
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