mTORC1 couples nucleotide synthesis to nucleotide demand resulting in a targetable metabolic vulnerability

The mechanistic target of rapamycin complex 1 (mTORC1) supports proliferation through parallel induction of key anabolic processes, including protein, lipid, and nucleotide synthesis. We hypothesized that these processes are coupled to maintain anabolic balance in cells with mTORC1 activation, a com...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Cancer Cell
Main Authors: Valvezan, Alexander J., Turner, Marc, Belaid, Amine, Lam, Hilaire C., Miller, Spencer K., McNamara, Molly C., Baglini, Christian, Housden, Benjamin E., Perrimon, Norbert, Kwiatkowski, David J., Asara, John M., Henske, Elizabeth P., Manning, Brendan D.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687294/
https://ncbi.nlm.nih.gov/pubmed/29056426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.09.013
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares