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The mTORC1 signaling network senses changes in cellular purine nucleotide levels
mTORC1 integrates signals from growth factors and nutrients to control biosynthetic processes, including protein, lipid and nucleic acid synthesis. We find that the mTORC1 pathway is responsive to changes in purine nucleotides in a manner analogous to its sensing of amino acids. Depletion of cellula...
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| Udgivet i: | Cell Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5689476/ https://ncbi.nlm.nih.gov/pubmed/29091770 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.029 |
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