The mTORC1 signaling network senses changes in cellular purine nucleotide levels

mTORC1 integrates signals from growth factors and nutrients to control biosynthetic processes, including protein, lipid and nucleic acid synthesis. We find that the mTORC1 pathway is responsive to changes in purine nucleotides in a manner analogous to its sensing of amino acids. Depletion of cellula...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Hoxhaj, Gerta, Hughes-Hallett, James, Timson, Rebecca, Ilagan, Erika, Yuan, Min, Asara, John M., Ben-Sahra, Issam, Manning, Brendan D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5689476/
https://ncbi.nlm.nih.gov/pubmed/29091770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.10.029
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