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Dual phosphorylation of Sin1 at T86 and T398 negatively regulates mTORC2 complex integrity and activity

Mammalian target of rapamycin (mTOR) plays essential roles in cell proliferation, survival and metabolism by forming at least two functional distinct multi-protein complexes, mTORC1 and mTORC2. External growth signals can be received and interpreted by mTORC2 and further transduced to mTORC1. On the...

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Autori principali: Liu, Pengda, Guo, Jianping, Gan, Wenjian, Wei, Wenyi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Higher Education Press 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3967077/
https://ncbi.nlm.nih.gov/pubmed/24481632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13238-014-0021-8
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