Inhibition of Rb phosphorylation leads to mTORC2-mediated activation of Akt

The retinoblastoma (Rb) protein exerts its tumor suppressor function primarily by inhibiting the E2F family of transcription factors that govern cell cycle progression. However, it remains largely elusive whether hyper-phosphorylated, non-E2F1-interacting form, of Rb has any physiological role. Here...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Cell
Auteurs principaux: Zhang, Jinfang, Xu, Kai, Liu, Pengda, Geng, Yan, Wang, Bin, Gan, Wenjian, Guo, Jianping, Wu, Fei, Chin, Y. Rebecca, Berrios, Christian, Lien, Evan C., Toker, Alex, DeCaprio, James A., Sicinski, Piotr, Wei, Wenyi
Format: Artigo
Langue:Inglês
Publié: 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4912424/
https://ncbi.nlm.nih.gov/pubmed/27237051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.023
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