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Inhibition of Rb phosphorylation leads to mTORC2-mediated activation of Akt

The retinoblastoma (Rb) protein exerts its tumor suppressor function primarily by inhibiting the E2F family of transcription factors that govern cell cycle progression. However, it remains largely elusive whether hyper-phosphorylated, non-E2F1-interacting form, of Rb has any physiological role. Here...

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Veröffentlicht in:	Mol Cell
Hauptverfasser:	Zhang, Jinfang, Xu, Kai, Liu, Pengda, Geng, Yan, Wang, Bin, Gan, Wenjian, Guo, Jianping, Wu, Fei, Chin, Y. Rebecca, Berrios, Christian, Lien, Evan C., Toker, Alex, DeCaprio, James A., Sicinski, Piotr, Wei, Wenyi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	2016
Schlagworte:	Article
Online Zugang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4912424/ https://ncbi.nlm.nih.gov/pubmed/27237051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.023
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Inhibition of Rb phosphorylation leads to mTORC2-mediated activation of Akt

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