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mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation
mTORC1 plays a key role in autophagy as a negative regulator. The currently-known targets of mTORC1 in the autophagy pathway mainly function at early stages of autophagosome formation. Here, we identify that mTORC1 inhibits later stages of autophagy by phosphorylating UVRAG. Under nutrient-enriched...
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| Publicado en: | Mol Cell |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4304967/ https://ncbi.nlm.nih.gov/pubmed/25533187 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.11.013 |
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