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ULK1 inhibits the kinase activity of mTORC1 and cell proliferation

ULK1 (Unc51-like kinase, hATG1) is a Ser/Thr kinase that plays a key role in inducing autophagy in response to starvation. ULK1 is phosphorylated and negatively regulated by the mammalian target of rapamycin complex 1 (mTORC1). Previous studies have shown that ULK1 is not only a downstream effector...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Jung, Chang Hwa, Seo, Minchul, Otto, Neil Michael, Kim, Do-Hyung
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210307/
https://ncbi.nlm.nih.gov/pubmed/21795849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.10.16660
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