The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

ULK1 (unc-51 like autophagy activating kinase 1), the key mediator of MTORC1 signaling to autophagy, regulates early stages of autophagosome formation in response to starvation or MTORC1 inhibition. How ULK1 regulates the autophagy induction process remains elusive. Here, we identify that ATG13, a b...

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Detalles Bibliográficos
Publicado en:Autophagy
Autores principales: Park, Ji-Man, Jung, Chang Hwa, Seo, Minchul, Otto, Neil Michael, Grunwald, Douglas, Kim, Kwan Hyun, Moriarity, Branden, Kim, Young-Mi, Starker, Colby, Nho, Richard Seonghun, Voytas, Daniel, Kim, Do-Hyung
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2016
Materias:
Basic Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835982/
https://ncbi.nlm.nih.gov/pubmed/27046250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1140293
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