ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

Protein synthesis and autophagy work as two opposing processes to control cell growth in response to nutrient supply. The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) pathway, which acts as a master regulator to control protein synthesis, has recently been shown to inhibit autophagy...

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Bibliografiska uppgifter
Huvudupphovsmän: Dunlop, Elaine A, Hunt, David K, Acosta-Jaquez, Hugo A, Fingar, Diane C, Tee, Andrew R
Materialtyp: Artigo
Språk:Inglês
Publicerad: Landes Bioscience 2011
Ämnen:
Basic Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149699/
https://ncbi.nlm.nih.gov/pubmed/21460630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.7.15491
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