ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

Protein synthesis and autophagy work as two opposing processes to control cell growth in response to nutrient supply. The mammalian/mechanistic target of rapamycin complex 1 (mTORC1) pathway, which acts as a master regulator to control protein synthesis, has recently been shown to inhibit autophagy...

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Bibliografske podrobnosti
Main Authors: Dunlop, Elaine A, Hunt, David K, Acosta-Jaquez, Hugo A, Fingar, Diane C, Tee, Andrew R
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2011
Teme:
Basic Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149699/
https://ncbi.nlm.nih.gov/pubmed/21460630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.7.15491
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